What is a Tretinoin cream? Tretinoin cream is a pharmaceutical drug in the dosage form of an ointment or cream formulation, that primarily contains vitamin A.  Tretinoin Cream belongs to the class of medications called retinoids. Tretinoin comes as a lotion (Altreno), cream (Avita, Refissa, Renova, Retin-A), and gel (Atralin, Avita, Retin-A). It’s also used as an...